Isoprenaline 1 – 10 micrograms/min IV infusion (0.05-1.0 microgram/kg/min in children).Atropine 0.01 – 0.03 mg/kg IV (usually 600 microgram boluses to a maximum of 1.8 mg).Is usually well tolerated and adjunctive therapy should only be considered if the patient is symptomatic with hypotension.CNS depression: Intubation and ventilation is usually only required in large overdoses.Metabolised by the live and exerted by the urine (although 50% is excreted unchanged).Large volume of distribution 3 – 6 L/kg.It act as a sympathoplegic agent and also increases endothelial nitric oxide levels and decreases renin activity.
It causes the classic triad of drowsiness, miosis and bradycardia in overdose.Ĭentrally acting alpha 2 adrenergic agonist. Clonidine has a vast array of uses including anxiety, ADHD, hypertension, withdrawal (opitates, alcohol and smoking), migraines, menopausal flushing, diarrhoea and finally pain.
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